The NANIVID : A New Device for Cancer Cell Migration Studies
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Abstract
Cancerous tumors are dynamic microenvironments that require unique analytical tools for their study. Better understanding of tumor microenvironments may reveal mechanisms behind tumor progression and generate new strategies for diagnostic marker development, which can be used routinely in histopathological analysis. Previous studies have shown that cell invasion and intravasation are related to metastatic potential and have linked these activities to gene expression patterns seen in migratory and invasive tumor cells in vivo. Existing analytical methods for tumor microenvironments include collection of tumor cells through a catheter needle loaded with a chemical or protein attractant (chemoattractant). This method has some limitations and restrictions, including time constraints of cell collection, long term anesthetization, and in vivo imaging inside the catheter. In this study, a novel implantable device was designed to replace the catheter-based method. The 1.5mm x 0.5mm x 0.24mm device is designed to controllably release chemoattractants for stimulation of tumor cell migration and subsequent cell capture. Devices were fabricated using standard microfabrication techniques and have been shown to mediate controlled release of bovine serum albumin (BSA) and epidermal growth factor (EGF). Optically transparent indium tin oxide (ITO) electrodes have been incorporated into the device for impedance-based measurement of cell density and have been shown to be compatible with in vivo multi-photon imaging of cell migration.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">The NANIVID : A New Device for Cancer Cell Migration Studies</title><author><name sortKey="Raja, Waseem K" uniqKey="Raja W">Waseem K. Raja</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>College of Nanoscale Science and Engineering, SUNYat Albany, 255 Fuller Rd</s1><s2>NY 12203</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Cady, Nathaniel C" uniqKey="Cady N">Nathaniel C. Cady</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>College of Nanoscale Science and Engineering, SUNYat Albany, 255 Fuller Rd</s1><s2>NY 12203</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Castracane, James" uniqKey="Castracane J">James Castracane</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>College of Nanoscale Science and Engineering, SUNYat Albany, 255 Fuller Rd</s1><s2>NY 12203</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Gligorijevic, Bojana" uniqKey="Gligorijevic B">Bojana Gligorijevic</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Albert Einstein College of Medicine, 1300 Morris Park Avenue</s1><s2>Bronx NY 10461</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bronx NY 10461</wicri:noRegion></affiliation></author><author><name sortKey="Van Rheenen, Jacco" uniqKey="Van Rheenen J">Jacco Van Rheenen</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Albert Einstein College of Medicine, 1300 Morris Park Avenue</s1><s2>Bronx NY 10461</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bronx NY 10461</wicri:noRegion></affiliation></author><author><name sortKey="Condeelis, John S" uniqKey="Condeelis J">John S. Condeelis</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Albert Einstein College of Medicine, 1300 Morris Park Avenue</s1><s2>Bronx NY 10461</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bronx NY 10461</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="inist">08-0428359</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0428359 INIST</idno><idno type="RBID">Pascal:08-0428359</idno><idno type="wicri:Area/Main/Corpus">006414</idno><idno type="wicri:Area/Main/Repository">005C34</idno></publicationStmt><seriesStmt><title level="j" type="main">Progress in biomedical optics and imaging</title></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Albumins</term><term>Analytical method</term><term>Diagnostic techniques</term><term>Experimental study</term><term>In vivo</term><term>Indium oxide</term><term>Measuring methods</term><term>Proteins</term><term>Theoretical study</term><term>Tin</term><term>Tumor cells</term><term>Tumours</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Etude théorique</term><term>Méthode analytique</term><term>Technique diagnostic</term><term>In vivo</term><term>Etude expérimentale</term><term>Méthode mesure</term><term>Tumeur</term><term>Cellule tumorale</term><term>Protéine</term><term>Albumine</term><term>Oxyde d'indium</term><term>Etain</term><term>0130C</term><term>8764</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cancerous tumors are dynamic microenvironments that require unique analytical tools for their study. Better understanding of tumor microenvironments may reveal mechanisms behind tumor progression and generate new strategies for diagnostic marker development, which can be used routinely in histopathological analysis. Previous studies have shown that cell invasion and intravasation are related to metastatic potential and have linked these activities to gene expression patterns seen in migratory and invasive tumor cells in vivo. Existing analytical methods for tumor microenvironments include collection of tumor cells through a catheter needle loaded with a chemical or protein attractant (chemoattractant). This method has some limitations and restrictions, including time constraints of cell collection, long term anesthetization, and in vivo imaging inside the catheter. In this study, a novel implantable device was designed to replace the catheter-based method. The 1.5mm x 0.5mm x 0.24mm device is designed to controllably release chemoattractants for stimulation of tumor cell migration and subsequent cell capture. Devices were fabricated using standard microfabrication techniques and have been shown to mediate controlled release of bovine serum albumin (BSA) and epidermal growth factor (EGF). Optically transparent indium tin oxide (ITO) electrodes have been incorporated into the device for impedance-based measurement of cell density and have been shown to be compatible with in vivo multi-photon imaging of cell migration.</div></front></TEI><inist><standard h6="B"><pA><fA05><s2>6859</s2></fA05><fA08 i1="01" i2="1" l="ENG"><s1>The NANIVID : A New Device for Cancer Cell Migration Studies</s1></fA08><fA09 i1="01" i2="1" l="ENG"><s1>Imaging, manipulation, and analysis of biomolecules, cells, and tissues VI : 21-23 January 2008, San Jose, California, USA</s1></fA09><fA11 i1="01" i2="1"><s1>RAJA (Waseem K.)</s1></fA11><fA11 i1="02" i2="1"><s1>CADY (Nathaniel C.)</s1></fA11><fA11 i1="03" i2="1"><s1>CASTRACANE (James)</s1></fA11><fA11 i1="04" i2="1"><s1>GLIGORIJEVIC (Bojana)</s1></fA11><fA11 i1="05" i2="1"><s1>VAN RHEENEN (Jacco)</s1></fA11><fA11 i1="06" i2="1"><s1>CONDEELIS (John S.)</s1></fA11><fA12 i1="01" i2="1"><s1>FARKAS (Daniel L.)</s1><s9>ed.</s9></fA12><fA12 i1="02" i2="1"><s1>LEIF (Robert C.)</s1><s9>ed.</s9></fA12><fA12 i1="03" i2="1"><s1>NICOLAU (Dan V.)</s1><s9>ed.</s9></fA12><fA14 i1="01"><s1>College of Nanoscale Science and Engineering, SUNYat Albany, 255 Fuller Rd</s1><s2>NY 12203</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="02"><s1>Albert Einstein College of Medicine, 1300 Morris Park Avenue</s1><s2>Bronx NY 10461</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA18 i1="01" i2="1"><s1>SPIE</s1><s3>USA</s3><s9>org-cong.</s9></fA18><fA20><s2>68591M.1-68591M.8</s2></fA20><fA21><s1>2008</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA26 i1="01"><s0>978-0-8194-7034-8</s0></fA26><fA43 i1="01"><s1>INIST</s1><s2>21760</s2><s5>354000172849110380</s5></fA43><fA44><s0>0000</s0><s1>© 2008 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>11 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>08-0428359</s0></fA47><fA60><s1>P</s1><s2>C</s2></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="2"><s0>Progress in biomedical optics and imaging</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Cancerous tumors are dynamic microenvironments that require unique analytical tools for their study. Better understanding of tumor microenvironments may reveal mechanisms behind tumor progression and generate new strategies for diagnostic marker development, which can be used routinely in histopathological analysis. Previous studies have shown that cell invasion and intravasation are related to metastatic potential and have linked these activities to gene expression patterns seen in migratory and invasive tumor cells in vivo. Existing analytical methods for tumor microenvironments include collection of tumor cells through a catheter needle loaded with a chemical or protein attractant (chemoattractant). This method has some limitations and restrictions, including time constraints of cell collection, long term anesthetization, and in vivo imaging inside the catheter. In this study, a novel implantable device was designed to replace the catheter-based method. The 1.5mm x 0.5mm x 0.24mm device is designed to controllably release chemoattractants for stimulation of tumor cell migration and subsequent cell capture. Devices were fabricated using standard microfabrication techniques and have been shown to mediate controlled release of bovine serum albumin (BSA) and epidermal growth factor (EGF). Optically transparent indium tin oxide (ITO) electrodes have been incorporated into the device for impedance-based measurement of cell density and have been shown to be compatible with in vivo multi-photon imaging of cell migration.</s0></fC01><fC02 i1="01" i2="3"><s0>001B00A30C</s0></fC02><fC02 i1="02" i2="X"><s0>002A08A</s0></fC02><fC03 i1="01" i2="3" l="FRE"><s0>Etude théorique</s0><s5>21</s5></fC03><fC03 i1="01" i2="3" l="ENG"><s0>Theoretical study</s0><s5>21</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Méthode analytique</s0><s5>23</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Analytical method</s0><s5>23</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Método analítico</s0><s5>23</s5></fC03><fC03 i1="03" i2="3" l="FRE"><s0>Technique diagnostic</s0><s5>30</s5></fC03><fC03 i1="03" i2="3" l="ENG"><s0>Diagnostic techniques</s0><s5>30</s5></fC03><fC03 i1="04" i2="3" l="FRE"><s0>In vivo</s0><s5>31</s5></fC03><fC03 i1="04" i2="3" l="ENG"><s0>In vivo</s0><s5>31</s5></fC03><fC03 i1="05" i2="3" l="FRE"><s0>Etude expérimentale</s0><s5>32</s5></fC03><fC03 i1="05" i2="3" l="ENG"><s0>Experimental study</s0><s5>32</s5></fC03><fC03 i1="06" i2="3" l="FRE"><s0>Méthode mesure</s0><s5>33</s5></fC03><fC03 i1="06" i2="3" l="ENG"><s0>Measuring methods</s0><s5>33</s5></fC03><fC03 i1="07" i2="3" l="FRE"><s0>Tumeur</s0><s5>61</s5></fC03><fC03 i1="07" i2="3" l="ENG"><s0>Tumours</s0><s5>61</s5></fC03><fC03 i1="08" i2="3" l="FRE"><s0>Cellule tumorale</s0><s5>62</s5></fC03><fC03 i1="08" i2="3" l="ENG"><s0>Tumor cells</s0><s5>62</s5></fC03><fC03 i1="09" i2="3" l="FRE"><s0>Protéine</s0><s5>63</s5></fC03><fC03 i1="09" i2="3" l="ENG"><s0>Proteins</s0><s5>63</s5></fC03><fC03 i1="10" i2="3" l="FRE"><s0>Albumine</s0><s2>NK</s2><s5>64</s5></fC03><fC03 i1="10" i2="3" l="ENG"><s0>Albumins</s0><s2>NK</s2><s5>64</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Oxyde d'indium</s0><s5>65</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Indium oxide</s0><s5>65</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Indio óxido</s0><s5>65</s5></fC03><fC03 i1="12" i2="3" l="FRE"><s0>Etain</s0><s2>NC</s2><s5>66</s5></fC03><fC03 i1="12" i2="3" l="ENG"><s0>Tin</s0><s2>NC</s2><s5>66</s5></fC03><fC03 i1="13" i2="3" l="FRE"><s0>0130C</s0><s4>INC</s4><s5>83</s5></fC03><fC03 i1="14" i2="3" l="FRE"><s0>8764</s0><s4>INC</s4><s5>84</s5></fC03><fN21><s1>280</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA><pR><fA30 i1="01" i2="1" l="ENG"><s1>Imaging, manipulation, and analysis of biomolecules, cells, and tissues</s1><s2>6</s2><s3>San Jose CA USA</s3><s4>2008</s4></fA30></pR></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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